Delta Virtual is based on the world's largest airline and its regional affiliates, Atlantic Southeast Airlines (ASA), Chautauqua Airlines, Comair, Compass Airlines, Freedom Airlines, Mesaba Airlines, Pinnacle Airlines, Shuttle America, and SkyWest Airlines. Delta Virtual also operates the routes of Delta Shuttle in the Northeast Corridor. Delta Virtual is SimAirline.net's largest and most active virtual airline.

In 1924, C.E. Woolman founded the Huff Daland Dusters, the first aerial crop-dusting company. The company changed names to Delta Air Service and began passenger service on 17 June 1929, flying from Dallas to Jackson via Shreveport and Monroe. The airline's headquarters later moved from Monroe to Atlanta in 1941, where it created the hub-and-spoke system in 1955. Delta merged with Chicago & Southern Airlines in 1953, adding service to the Caribbean and South America. Delta introduced the first domestic jet service on 18 September 1959 with the DC-8, which it was the first operator of. Delta was also the first airline to fly the Convair 880 (1960), DC-9 (1965), MD-11 (1991).

Delta expanded its East Coast presence in 1972 by merging with Northeast Airlines, which led to it becoming the world's largest 727 operator. Delta was also the largest operator of the L-1011, with which it began transatlantic service in 1978. In 1982, Delta employees raised $30 million through payroll deductions to buy the first 767, named The Spirit of Delta. Delta is today the largest 767 operator in the world. Delta bought Western Airlines and began transpacific service in 1987, and in its biggest merger, purchased Pan American's European network and what would become the Delta Shuttle in 1991.

Comair, based in Cincinnati and founded in 1977, was acquired by Delta in 2000. Comair was the launch customer for the CRJ, and is today the world's largest operator. ASA, based in Atlanta, began operations in 1979 and was acquired twenty years later before being sold to Delta Connection partner SkyWest in 2005.

Delta has been the host airline for the Olympics twice: Atlanta in 1996 and Salt Lake City in 2002. The airline was a founding member of SkyTeam in 2000, today the fastest growing airline alliance in the world. Delta announced a major restructuring of its operations in September 2004, which included closing its Dallas/Ft. Worth hub on 31 January 2005, and filed for bankruptcy in September 2005, emerging in April 2007. Delta bought Northwest Airlines in October 2008.

Headquarters: Delta - Atlanta, GA, U.S.; ASA - Atlanta, GA, U.S.; Chautauqua - Indianapolis, IN, U.S.; Comair - Erlanger, KY, U.S.; Compass - Chantilly, VA, U.S.; Freedom - Irving, TX, U.S.; Mesaba - Eagan, MN, U.S.; Pinnacle - Memphis, TN, U.S.; Shuttle America - Ft. Wayne, IN, U.S.; SkyWest - St. George, UT, U.S.
Virtual Airline Operating Since: February 2003
Unique Aircraft Types: A310-300, 767-300ERW, CRJ-700ER, EMB-110, L-1011-1, MD-88, MD-90
Number of Destinations: 424
Unique Destinations (47): Albany (GA), Brunswick, Cape Girardeau, Cedar City, Cody, Culiacan, Elko, Ely, Fayetteville (NC), Florence (SC), Gillette, Hickory, Huntington, Imperial, Inyokern, Jacksonville (NC), Kinston, Lawton/Ft. Still, Longview, Los Mochis, Lynchburg, Macon, Massena, Monterey, Newport News, Ogdensburg, Owensboro, Page/Lake Powell (AZ), Palmdale, Plattsburgh, Rock Springs, Salem, San Luis Obispo, Santa Maria (CA), Saranac Lake, Southern Pines, Springfield (IL), St. George (UT), Tijuana, Trenton, Valdosta, Vernal, Watertown (NY), West Yellowstone, Wichita Falls, Wilmington (DE), Yuma